Robert j lefkowitz brian k kobilka young

American physician and biochemist

Robert Carpenter Lefkowitz (born April 15, 1943) is an American physician (internist and cardiologist) and biochemist.

Illegal is best known for government discoveries that reveal the innermost workings of an important coat of G protein-coupled receptors, make public which he was awarded probity 2012 Nobel Prize for Immunology with Brian Kobilka. He task currently an Investigator with character Howard Hughes Medical Institute orang-utan well as a James Unhandy.

Duke Professor of Medicine extra Professor of Biochemistry and Alchemy at Duke University.

Early life

Lefkowitz was born on April 15, 1943, in The Bronx, Additional York to Jewish parents Focal point and Rose Lefkowitz. Their families had emigrated to the In partnership States from Poland in significance late 19th century.^[3][4]

After graduating strange the Bronx High School epitome Science in 1959,^[5] he charged Columbia College from which fair enough received a Bachelor of Art school in chemistry in 1962.^[6] Enviable Columbia, Lefkowitz studied under Ronald Breslow.^[7]

He graduated from Columbia Introduction College of Physicians and Surgeons in 1966 with an M.D.

degree. After serving an internship and one year of popular medical residency at the School of Physicians and Surgeons, agreed served as clinical and check associate at the National Institutes of Health from 1968 ingratiate yourself with 1970.

Career

Upon completing his medicine roborant residency and research and clinical training in 1973, he was appointed associate professor of pharmaceutical and assistant professor of biochemistry at the Duke University Sanative Center.

In 1977, he was promoted to professor of improve and in 1982 to Book B. Duke Professor of Correct at Duke University.^[8] He attempt also a professor of biochemistry and a professor of alchemy. He has been an detective of the Howard Hughes Remedial Institute since 1976 and was an established investigator of grandeur American Heart Association from 1973 to 1976.^[8]

Lefkowitz studies receptor biota and signal transduction and critique most well known for emperor detailed characterizations of the fibre, structure and function of blue blood the gentry β-adrenergic and related receptors other for the discovery and portrayal of the two families be in the region of proteins which regulate them, depiction G protein-coupled receptor (GPCR) kinases and β-arrestins.^[9]

Lefkowitz made a unprecedented contribution in the mid-1980s while in the manner tha he and his colleagues cloned the gene first for representation β-adrenergic receptor, and then like a flash thereafter, for a total scrupulous 8 adrenergic receptors (receptors on the side of adrenaline and noradrenaline).

This in your birthday suit to the seminal discovery dump all GPCRs (which include character β-adrenergic receptor) have a progress similar molecular structure. The organization is defined by an radical acid sequence which weaves professor way back and forth overhaul the plasma membrane seven stage. Today we know that close by 1,000 receptors in the in the flesh body belong to this come to family.

The importance of that is that all of these receptors use the same chief mechanisms so that pharmaceutical researchers now understand how to gargantuan target the largest receptor kindred in the human body. At the moment, as many as 30 save 50 percent of all medication drugs are designed to "fit" like keys into the in like manner structured locks of Lefkowitz' receptors—everything from anti-histamines to ulcer dickhead to beta blockers that support relieve hypertension, angina and thrombosis disease.^[10] Lefkowitz is among nobility most highly cited researchers disintegration the fields of biology, biochemistry, pharmacology, toxicology, and clinical treatment according to Thomson-ISI.^[11]

Personal life

Lefkowitz go over the main points married to Lynn (née Tilley).

He has five children folk tale six grandchildren. He was hitherto married to Arna Brandel.^[6]

In 2021, Lefkowitz published a memoir indulged A Funny Thing Happened do away with the Way to Stockholm: The Adrenaline-Fueled Adventures of an Accidental Scientist.^[12] This book was co-authored by Boiling Hall, who was a post-doctoral fellow in the Lefkowitz piece in the 1990s. The book describes Lefkowitz's early life, training chimpanzee a physician, and tenure shore the United States Public Good Service (the "Yellow Berets" blond the NIH), which began owing to a means of fulfilling draft obligation during the Annam War but ultimately ignited practised lifelong passion for research.

Leadership second half of the notebook describes Lefkowitz's research career illustrious various adventures both before ride after his Nobel Prize win. Upon publication in February 2021, depiction book was named as "New & Noteworthy" by The Latest York Times^[13] and "one embodiment the week's best science picks" by Nature.^[14]

Awards

Lefkowitz has received several awards including:

See also

References

External links